In a laboratory setting, contamination refers to the presence of an undesired living organism or other chemical pollutant in an experiment. For example, when working with a cell cultureCell culture refers to the growth of any type of cell (ie, plant, microbial, or animal) under contro it is common to observe contamination with bacteria or fungi, as the environment is optimal for these organisms to thrive. Researchers must follow strict sterile working conditions or use drugs, such as antibiotics, to avoid contamination. The use of antibiotics in cell cultureCell culture refers to the growth of any type of cell (ie, plant, microbial, or animal) under contro is discouraged, though is still widely used. Antibiotic use can lead to the development of antibiotic resistant strainsWithin biology, a strain refers to a distinct variant or subtype of an organism. For example, flu st of microorganismsMicroorganisms are living beings that cannot be seen with the naked eye. ‘Micro’ is a prefix tha and the persistence of low-level contamination in cultures. The long-term impacts of antibiotic use in cell cultureCell culture refers to the growth of any type of cell (ie, plant, microbial, or animal) under contro is yet to be thoroughly investigated, but some studies suggest they can induce changes in gene expression in the cultured cells.